Wuxi Maternity and Child Health Care Hospital | China
Dr. Zhice Xu, M.D., Ph.D., is an accomplished Professor and Director of the Wuxi Key Laboratory of Perinatal Bio-Medicine at Wuxi Maternity and Child Health Care Hospital, China. With over three decades of academic and research experience, Dr. Xu has built an exceptional career that bridges basic science and clinical medicine. He earned his medical and cardiovascular degrees from Suzhou Medical College and completed his Ph.D. at the University of Cambridge, U.K., followed by postdoctoral training at the University of Iowa and faculty appointments at UCLA and Loma Linda University in the United States. His major research interests focus on fetal cardiovascular research, fetal-originated cardiovascular and metabolic diseases, placental-fetal circulation, and cardiovascular physiology. Dr. Xu has led numerous studies elucidating the mechanisms of fetal cardiovascular adaptation and the developmental origins of adult cardiovascular disease. He has completed 11 major research projects with 2 ongoing, published over 150 SCI and Scopus-indexed articles, and authored two academic books with ISBNs. His impactful body of work includes 167 indexed documents, 2,926 citations, and an h-index of 29, reflecting his significant global research influence. In addition, he holds three patents, serves on editorial boards for Frontiers in Endocrinology and Journal of Personalized Medicine (JPM), and continues to advance international collaborations in perinatal and cardiovascular research.
Profiles: Scopus | Orcid
Featured Publications
He, Q., Zheng, Q., Liu, Y., Miao, Y., Zhang, Y., Xu, T., Bai, S., Zhao, X., Yang, X., & Xu, Z. (2023). High-salt diet causes defective oocyte maturation and embryonic development to impair female fertility in mice. Molecular Nutrition & Food Research, 67(23), e2300401.
Tang, J., Qi, L., He, Y., Li, N., Zhang, Z., Zhou, X., Su, H., Zheng, Q., Zhang, Y., Tao, J., & Xu, Z. (2023). In vitro fertilization with frozen embryo transfer increased histamine-mediated contractile sensitivity via PKCβ in human umbilical vein. Reproductive Biology and Endocrinology, 21(1), 54.
Tang, J., Zhang, Y., Zhang, Z., Tao, J., Wu, J., Zheng, Q., Xu, T., Li, N., & Xu, Z. (2023). Specific dilation pattern in placental circulation and the NO/sGC role in preeclampsia placental vessels. Frontiers in Endocrinology, 14, 1182636.
Zheng, Q., He, Y., Li, L., Rui, C., Li, N., Zhang, Y., Ye, Y., Zhang, Z., Yang, X., Tang, J., & Xu, Z. (2023). Perinatal fat diets increased angiotensin II–mediated Ca²⁺ through PKC–L-type calcium channel axis in resistance arteries via Agtr1a–Prkcb gene methylation. Nutrients, 15(1), 245.
Zhang, Y., Pu, J., Ding, Y., Wu, L., Yin, Y., Sun, M., Gu, Y., Zhang, D., Zhang, Z., Zheng, Q., He, Q., Xu, T., He, Y., Su, H., Zhou, X., Li, L., Ye, Y., Li, J., & Xu, Z. (2022). Sex differences at early old stage in glycolipid metabolism and fatty liver in offspring prenatally exposed to the Chinese Great Famine. Frontiers in Nutrition, 9, 913966.
He, Y., Su, H., Li, N., Zhang, Y., Zhang, P., Zhang, Y., Ye, Y., Zhang, Y., Tang, J., & Xu, Z. (2022). In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: Role of ROS/ERK1/2. Hypertension Research, 45(7), 1168–1182.