Prof. Dr. Ruping Dai, Second Xiangya Hospital, China
Prof. Dr. Ruping Dai is the Director of Anesthesiology at the Second Xiangya Hospital, Central South University, China. He earned his Ph.D. in Clinical Medicine from the National University of Singapore in 2004 and completed postdoctoral research at the Institute of Molecular and Cell Biology, Singapore. Prof. Dai specializes in clinical anesthesia, pain management, intensive care, perioperative medicine, and organ protection. He has led four projects funded by the National Natural Science Foundation of China and has published 24 SCI papers. His accolades include the New Century Talent Support Program (2012) and the Hunan Province Outstanding Youth Fund (2013).
AUTHOR PROFILE
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🎓EARLY ACADEMIC PURSUITS:
Prof. Dr. Ruping Dai embarked on his academic journey at the Xiangya School of Medicine, Central South University, where he earned his Bachelor’s degree in Anesthesiology (1993-1998). His thirst for knowledge led him to pursue a Ph.D. in Medicine at the National University of Singapore (2000-2004), where he focused on advanced medical research. He further honed his expertise as a Postdoctoral Fellow at the National Institute of Molecular and Cell Biology, Singapore (2004-2006), gaining in-depth knowledge in molecular and cellular biology applications in anesthesiology.
🏥PROFESSIONAL ENDEAVORS:
Dr. Dai began his career in the Department of Cardiothoracic Surgery, Union Hospital Affiliated to Fujian Medical University (1998-2000), specializing in cardiovascular anesthesia and intensive care. Since October 2006, he has been a Chief Physician and Doctoral Supervisor at the Department of Anesthesiology, Second Xiangya Hospital, Central South University. Over the years, he has played a vital role in clinical anesthesia and Anesthesia Intensive Care Units (AICU), ensuring excellence in patient care and medical education.
Dr. Dai’s research primarily focuses on anesthesiology, organ protection, perioperative care, and immunosuppression mechanisms in sepsis. He has led multiple groundbreaking studies on topics such as:
- Postoperative sepsis mechanisms
- Perioperative acute lung injury
- Neuroplasticity and postoperative cognitive dysfunction (POCD)
- Microglial/macrophage polarization in spinal cord ischemia-reperfusion injury
Dr. Dai has hosted 7 National Natural Science Foundation (NSFC) projects, receiving significant research funding, including:
- Key Project on Hematogenous Macrophage Role in Postoperative Sepsis (2025-2028) – RMB 2.6 million
- SIRT5-Mitochondrial Metabolic Axis in Perioperative Acute Lung Injury (2024-2027) – RMB 490,000
- Macrophage Dysfunction in Sepsis Immunosuppression (2021-2024) – RMB 560,000
- Microglia Polarization in Spinal Cord Ischemia-Reperfusion Injury (2018-2021) – RMB 540,000
🌍IMPACT AND INFLUENCE:
Dr. Dai holds several prestigious administrative positions, including:
- Director of Anesthesiology, Second Xiangya Hospital, Central South University
- Director, Institute of Anesthesiology, Central South University
- Director, Hunan Anesthesia Clinical Medicine Research Center
- Director, Hunan Provincial Organ Damage Prevention and Treatment Engineering Center
In academia, he serves as:
- Deputy Chairman, Hunan Provincial Anesthesiology Committee
- National Committee Member, Anesthesiology Branch, Chinese Medical Doctor Association
- Vice Chairman, 13th Youth Committee of the Chinese Medical Association Anesthesiology Branch
- Deputy Director, Orthopedics Group, Chinese Medical Association Anesthesiology Branch
- Standing Committee Member, Cardiovascular Anesthesia Branch, Chinese Society of Thoracic and Cardiovascular Anesthesiology
📖ACADEMIC CITES AND SCHOLARLY CONTRIBUTIONS:
Dr. Dai has played a crucial role in education, having authored and co-edited several key textbooks:
- Clinical Anesthesiology (First Editor, Science Press, 14th Five-Year Plan)
- Postgraduate Textbook: Anesthesiology (Selected Topics of Basic Anesthesia Research, People’s Medical Publishing House, 2014)
- Resident Medical Planning Textbook: Anesthesiology (Postoperative Acute Pain Management, People’s Medical Publishing House, 2014)
- Co-translator of Miller’s Anesthesiology (7th & 8th editions, Opioids section, 2017)
🏆SCIENCE AND TECHNOLOGY AWARDS:
Dr. Dai’s excellence in research and innovation has earned him several prestigious awards, including:
- Second Prize of Hunan Natural Science Award (2019)
- Third “Light of Spirit” Excellent Youth Research Fund – Second Prize
- Award-winning fund for Young and Middle-aged Excellent Paper Competition at the Chinese Anesthesia Annual Meeting
🔮LEGACY AND FUTURE CONTRIBUTIONS:
As a pioneering figure in anesthesiology, Dr. Dai continues to shape the future of perioperative medicine, critical care, and pain management. His leadership in cutting-edge research, education, and healthcare innovation ensures his lasting impact in the field. Through mentorship and research, he remains dedicated to improving patient outcomes and advancing medical science, setting a benchmark for future anesthesiologists worldwide.
🌟CONCLUSION:
Prof. Dr. Ru-Ping Dai is a distinguished anesthesiologist and researcher at the Second Xiangya Hospital, Central South University, China. As the Director of the Department of Anesthesiology, he has significantly advanced perioperative medicine, focusing on neuroimmune interactions and organ protection. His notable work includes elucidating the roles of brain-derived neurotrophic factor (BDNF) and its precursor, pro-BDNF, in mood disorders, offering new perspectives on neuroimmune crosstalk. Prof. Dai’s dedication to integrating clinical practice with research has enhanced patient care and contributed to the global medical community’s understanding of anesthesiology and neuroscience.
TOP NOTABLE PUBLICATIONS
Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats
Authors: CQ Li, JM Xu, D Liu, JY Zhang, RP Dai
Journal: Molecular Pain
Year: 2008
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity
Authors: OK Melemedjian, DV Tillu, JK Moy, MN Asiedu, EK Mandell, S Ghosh, …
Journal: Molecular Pain
Year: 2014
Early-life social isolation-induced depressive-like behavior in rats results in microglial activation and neuronal histone methylation that are mitigated by minocycline
Authors: HT Wang, FL Huang, ZL Hu, WJ Zhang, XQ Qiao, YQ Huang, RP Dai, F Li, …
Journal: Neurotoxicity Research
Year: 2017
Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status
Authors: RP Dai, FX Yu, SR Goh, HW Chng, YL Tan, JL Fu, L Zheng, Y Luo
Journal: Journal of Biological Chemistry
Year: 2008
Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways
Authors: W Ruan, J Xu, S Li, L Yuan, R Dai
Journal: Cardiovascular Research
Year: 2012
Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment
Authors: CQ Li, YW Luo, FF Bi, TT Cui, L Song, WY Cao, JY Zhang, F Li, JM Xu, …
Journal: Neuropsychopharmacology
Year: 2014
Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study
Authors: L He, JM Xu, RP Dai
Journal: Upsala Journal of Medical Sciences
Year: 2012
Adipocyte fatty acid-binding protein promotes palmitate-induced mitochondrial dysfunction and apoptosis in macrophages
Authors: H Li, Y Xiao, L Tang, F Zhong, G Huang, JM Xu, AM Xu, RP Dai, ZG Zhou
Journal: Frontiers in Immunology
Year: 2018
Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress
Authors: YW Luo, Y Xu, WY Cao, XL Zhong, J Duan, XQ Wang, ZL Hu, F Li, …
Journal: Neuropharmacology
Year: 2015
Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical …
Authors: RP Dai, CQ Li, JW Zhang, F Li, XD Shi, JY Zhang, XF Zhou
Journal: Anesthesiology
Year: 2011