Guangdong Provincial People's Hospital | China
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🌟 DR. YAN SHI: PIONEERING GENETICS RESEARCHER IN CARDIOVASCULAR DEVELOPMENT 🧬❤️
🎓 EARLY ACADEMIC PURSUITS
Yan Shi , a dedicated scientist from China, embarked on her academic journey in the field of life sciences with an undergraduate degree in Biological Engineering from Shenyang University (2008-2012). She continued to follow her passion for genetics at Hunan Normal University, earning a Master’s Degree in Genetics (2012-2014), and later completed her Ph.D. in Genetics in 2019. Throughout her studies, she developed a strong foundation in molecular biology, focusing on the genetic mechanisms underlying human diseases.
🏥 PROFESSIONAL ENDEAVORS
After obtaining her Ph.D., Dr. Yan Shi advanced her career through postdoctoral research at the Department of Pediatric Cardiac Surgery, Guangdong Provincial People's Hospital (2019-2024). In July 2024, she took on a significant role as a Researcher at the South China Key Laboratory of Structural Heart Disease, where she continues to contribute to groundbreaking cardiovascular research.
Dr. Yan Shi's primary research focuses on the molecular mechanisms of congenital and familial heart diseases, especially:
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Tetralogy of Fallot (TOF)
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Familial Dilated Cardiomyopathy (DCM)
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Wnt signaling pathways in cardiac development
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Single coronary artery animal models
She has successfully led and participated in several national-level projects, including:
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SORBS2's role in familial dilated cardiomyopathy via the AKT pathway (2024-2027).
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NOTCH1 point mutations leading to Tetralogy of Fallot (2022-2024).
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Establishing an animal model for single coronary artery using mice (2020-2022).
🏅 IMPACT AND INFLUENCE
Dr. Yan Shi’s work has been widely recognized in the academic community. She has published several influential papers in reputable journals as the first, co-first, or corresponding author, covering:
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Wnt signaling and cardiomyocyte differentiation
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NOTCH1 mutations in congenital heart disease
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Genetic polymorphisms in BVES associated with Tetralogy of Fallot
Additionally, she was a contributor to a team that won the First-Class Guangdong Natural Science Award (2020) for their research on genes regulating cardiovascular development.
📚 ACADEMIC CITES
Her published research has been cited in various genetic, developmental biology, and cardiovascular journals. Some of her notable publications include:
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"Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease" – Corresponding Author
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"Novel biphasic mechanism of the canonical Wnt signaling component PYGO2 promotes cardiomyocyte differentiation" – First Author
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"Structure and function of Pygo in organ development" – First Author
🚀 LEGACY AND FUTURE CONTRIBUTIONS
As an emerging leader in the field of genetic cardiology, Dr. Yan Shi’s legacy is shaped by her contributions to understanding the genetic underpinnings of heart disease, which hold promise for improving clinical diagnostics and therapies for congenital heart conditions. Her future work is expected to explore further genetic pathways and their therapeutic targeting, potentially leading to personalized treatments for heart diseases.
📑 NOTABLE PUBLICATIONS
"Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUCMSCs"
Authors: Y Shi, B Qin, X Fan, Y Li, Y Wang, W Yuan, Z Jiang, P Zhu, J Chen, Y Chen, F Li, Y Wan
Journal: Cell and Tissue Research
Year: 2023
"Structure and function of Pygo in organ development dependent and independent Wnt signalling"
Authors: Y Shi, X Wu, S Zhu, H Huang, J Zhuang, H Yuan, W Yuan, P Zhu
Journal: Biochemical Society Transactions
Year: 2020