Yan Shi | Congenital Heart Defects | Best Researcher Award

Published on by Cardiology and Cardiovascular Medicine

Dr. Yan Shi | Congenital Heart Defects | Best Researcher Award

Guangdong Provincial People's Hospital | China

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🌟 DR. YAN SHI: PIONEERING GENETICS RESEARCHER IN CARDIOVASCULAR DEVELOPMENT 🧬❤️

🎓 EARLY ACADEMIC PURSUITS

Yan Shi , a dedicated scientist from China, embarked on her academic journey in the field of life sciences with an undergraduate degree in Biological Engineering from Shenyang University (2008-2012). She continued to follow her passion for genetics at Hunan Normal University, earning a Master’s Degree in Genetics (2012-2014), and later completed her Ph.D. in Genetics in 2019. Throughout her studies, she developed a strong foundation in molecular biology, focusing on the genetic mechanisms underlying human diseases.

🏥 PROFESSIONAL ENDEAVORS

After obtaining her Ph.D., Dr. Yan Shi advanced her career through postdoctoral research at the Department of Pediatric Cardiac Surgery, Guangdong Provincial People's Hospital (2019-2024). In July 2024, she took on a significant role as a Researcher at the South China Key Laboratory of Structural Heart Disease, where she continues to contribute to groundbreaking cardiovascular research.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON CONGENITAL HEART DEFECTS

Dr. Yan Shi's primary research focuses on the molecular mechanisms of congenital and familial heart diseases, especially:

  • Tetralogy of Fallot (TOF)

  • Familial Dilated Cardiomyopathy (DCM)

  • Wnt signaling pathways in cardiac development

  • Single coronary artery animal models

She has successfully led and participated in several national-level projects, including:

  • SORBS2's role in familial dilated cardiomyopathy via the AKT pathway (2024-2027).

  • NOTCH1 point mutations leading to Tetralogy of Fallot (2022-2024).

  • Establishing an animal model for single coronary artery using mice (2020-2022).

🏅 IMPACT AND INFLUENCE

Dr. Yan Shi’s work has been widely recognized in the academic community. She has published several influential papers in reputable journals as the first, co-first, or corresponding author, covering:

  • Wnt signaling and cardiomyocyte differentiation

  • NOTCH1 mutations in congenital heart disease

  • Genetic polymorphisms in BVES associated with Tetralogy of Fallot

Additionally, she was a contributor to a team that won the First-Class Guangdong Natural Science Award (2020) for their research on genes regulating cardiovascular development.

📚 ACADEMIC CITES

Her published research has been cited in various genetic, developmental biology, and cardiovascular journals. Some of her notable publications include:

  • "Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease" – Corresponding Author

  • "Novel biphasic mechanism of the canonical Wnt signaling component PYGO2 promotes cardiomyocyte differentiation" – First Author

  • "Structure and function of Pygo in organ development" – First Author

🚀 LEGACY AND FUTURE CONTRIBUTIONS

As an emerging leader in the field of genetic cardiology, Dr. Yan Shi’s legacy is shaped by her contributions to understanding the genetic underpinnings of heart disease, which hold promise for improving clinical diagnostics and therapies for congenital heart conditions. Her future work is expected to explore further genetic pathways and their therapeutic targeting, potentially leading to personalized treatments for heart diseases.

📑 NOTABLE PUBLICATIONS

"Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUCMSCs"

Authors: Y Shi, B Qin, X Fan, Y Li, Y Wang, W Yuan, Z Jiang, P Zhu, J Chen, Y Chen, F Li, Y Wan
Journal: Cell and Tissue Research
Year: 2023

"Structure and function of Pygo in organ development dependent and independent Wnt signalling"

Authors: Y Shi, X Wu, S Zhu, H Huang, J Zhuang, H Yuan, W Yuan, P Zhu
Journal: Biochemical Society Transactions
Year: 2020

Tunç Tunçer | Pediatric Cardiology | Best Researcher Award

Published on by Cardiology and Cardiovascular Medicine
Assist Prof Dr. Tunç Tunçer, Bülent Ecevit University School of Medicine, Turkey

Assoc. Prof. Dr. Tunç Tunçer is a faculty member at the School of Medicine, Bülent Ecevit University, Turkey. He specializes in medical education and research, with a focus on clinical practices. Dr. Tunçer contributes actively to both teaching and research initiatives, working closely with students and colleagues to advance the medical field. His research interests include advancements in medical techniques and patient care, with a dedication to improving healthcare outcomes. Dr. Tunçer is known for his commitment to excellence in education and his role in shaping the next generation of medical professionals.

Profile:
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Education:

Assist. Prof. Dr. Tunç Tunçer earned his M.D. from Marmara University School of Medicine in 2000. He completed his pediatrics residency in 2005 and further specialized by completing a pediatric cardiology residency in 2014. His advanced training in both pediatrics and pediatric cardiology has equipped him with a strong foundation for his work as a Pediatric Cardiologist.

Professional Experience:

Assist. Prof. Dr. Tunç Tunçer worked as a Pediatric Cardiologist at several Training and Research Hospitals from 2015 to 2022, gaining extensive clinical experience. In 2022, he joined Zonguldak Bülent Ecevit University School of Medicine as an Assistant Professor, where he continues to serve as a Pediatric Cardiologist, contributing to both academic and clinical advancements in pediatric cardiology.

Research Interests:

Assist. Prof. Dr. Tunç Tunçer’s research focuses on critical areas of pediatric cardiology, including the cardiac complications related to COVID-19, advancements in fetal medicine, and the diagnosis and treatment of congenital heart diseases. His work aims to improve understanding and outcomes in these complex and evolving medical fields.

Conclusion:

In summary, Assist. Prof. Dr. Tunç Tunçer is a dedicated Pediatric Cardiologist and Assistant Professor at Zonguldak Bülent Ecevit University School of Medicine. With a solid educational background, extensive professional experience, and active research interests in COVID-19-related cardiac diseases, fetal medicine, and congenital heart diseases, he continues to contribute significantly to both the clinical and academic fields. His work reflects a commitment to improving pediatric healthcare and advancing medical knowledge.

Top Notable Publications:

Cardiovascular Outcomes in Children with Multisystem Inflammatory Syndrome Treated with Therapeutic Plasma Exchange

Authors: Tunçer, T., Varol, F.

Year: 2022

Citations: 3

Efficacy of Extracorporeal Membrane Oxygenation in Pediatric COVID-19 and MIS-C Cases: A Single-Center Experience

Authors: Varol, F., Şahin, E., Kılıç, A., Tunçer, T., Çam, H.

Year: 2022

Citations: 1

Management of Life-Threatening Flecainide Overdose: A Case Report of an Infant

Authors: Tuncer, T.

Year: 2021

Citations: 0

Patterns of Myocardial Involvement During COVID-19 Pandemic; From Newborn to Adolescents

Authors: Tunçer, T., Varol, F., Coşkun, Ş., Güven, Ş., Çam, H.

Year: 2021

Citations: 2

Is There Myocardial Involvement in Children with Long-Term Follow-Up for Kawasaki Disease? A Study Based on Two-Dimensional Speckle Tracking Echocardiography

Authors: Kayabey, Ö., Tuncer, T., Deveci, M., Başar, E.Z., Babaoğlu, K.

Year: 2021

Citations: 1

QT Interval Evaluation Associated with the Use of Hydroxychloroquine with Combined Use of Azithromycin Among Hospitalised Children Positive for Coronavirus Disease 2019

Authors: Tuncer, T., Karaci, M., Boga, A., Durmaz, H., Guven, S.

Year: 2020

Citations: 11

Effects of Atrial Septal Defect Transcatheter Closure on Parameters of Right Ventricular Functions

Authors: Tosun, Ö., Ödemiş, E., Tuncer, V.T., Demir, H.I., Güzeltaş, A.

Year: 2016

Citations: 2

The Evaluation of the Effect of Air Pollution on the Health Status of Children in Zonguldak City, Turkey

Authors: Tecer, L.H., Tomaç, N., Karaca, F., Tunçer, T., Aydin, H.

Year: 2009

Citations: 7