Dr. Yan Shi | Congenital Heart Defects | Best Researcher Award

Guangdong Provincial People's Hospital | China

Author Profile:

🌟 DR. YAN SHI: PIONEERING GENETICS RESEARCHER IN CARDIOVASCULAR DEVELOPMENT 🧬❤️

🎓 EARLY ACADEMIC PURSUITS

Yan Shi , a dedicated scientist from China, embarked on her academic journey in the field of life sciences with an undergraduate degree in Biological Engineering from Shenyang University (2008-2012). She continued to follow her passion for genetics at Hunan Normal University, earning a Master’s Degree in Genetics (2012-2014), and later completed her Ph.D. in Genetics in 2019. Throughout her studies, she developed a strong foundation in molecular biology, focusing on the genetic mechanisms underlying human diseases.

🏥 PROFESSIONAL ENDEAVORS

After obtaining her Ph.D., Dr. Yan Shi advanced her career through postdoctoral research at the Department of Pediatric Cardiac Surgery, Guangdong Provincial People's Hospital (2019-2024). In July 2024, she took on a significant role as a Researcher at the South China Key Laboratory of Structural Heart Disease, where she continues to contribute to groundbreaking cardiovascular research.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON CONGENITAL HEART DEFECTS

Dr. Yan Shi's primary research focuses on the molecular mechanisms of congenital and familial heart diseases, especially:

Tetralogy of Fallot (TOF)
Familial Dilated Cardiomyopathy (DCM)
Wnt signaling pathways in cardiac development
Single coronary artery animal models

She has successfully led and participated in several national-level projects, including:

SORBS2's role in familial dilated cardiomyopathy via the AKT pathway (2024-2027).
NOTCH1 point mutations leading to Tetralogy of Fallot (2022-2024).
Establishing an animal model for single coronary artery using mice (2020-2022).

🏅 IMPACT AND INFLUENCE

Dr. Yan Shi’s work has been widely recognized in the academic community. She has published several influential papers in reputable journals as the first, co-first, or corresponding author, covering:

Wnt signaling and cardiomyocyte differentiation
NOTCH1 mutations in congenital heart disease
Genetic polymorphisms in BVES associated with Tetralogy of Fallot

Additionally, she was a contributor to a team that won the First-Class Guangdong Natural Science Award (2020) for their research on genes regulating cardiovascular development.

📚 ACADEMIC CITES

Her published research has been cited in various genetic, developmental biology, and cardiovascular journals. Some of her notable publications include:

"Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease" – Corresponding Author
"Novel biphasic mechanism of the canonical Wnt signaling component PYGO2 promotes cardiomyocyte differentiation" – First Author
"Structure and function of Pygo in organ development" – First Author

🚀 LEGACY AND FUTURE CONTRIBUTIONS

As an emerging leader in the field of genetic cardiology, Dr. Yan Shi’s legacy is shaped by her contributions to understanding the genetic underpinnings of heart disease, which hold promise for improving clinical diagnostics and therapies for congenital heart conditions. Her future work is expected to explore further genetic pathways and their therapeutic targeting, potentially leading to personalized treatments for heart diseases.

📑 NOTABLE PUBLICATIONS

"Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUCMSCs"

Authors: Y Shi, B Qin, X Fan, Y Li, Y Wang, W Yuan, Z Jiang, P Zhu, J Chen, Y Chen, F Li, Y Wan
Journal: Cell and Tissue Research
Year: 2023

"Structure and function of Pygo in organ development dependent and independent Wnt signalling"

Authors: Y Shi, X Wu, S Zhu, H Huang, J Zhuang, H Yuan, W Yuan, P Zhu
Journal: Biochemical Society Transactions
Year: 2020

Dr. Ling Chen | Cardiac Surgery | Best Researcher Award

Dr. Ling Chen, Fujian union hospital, China

Dr. Ling Chen is a renowned cardiac surgeon at Fujian Medical University Affiliated Union Hospital, China. Specializing in aortic dissection, heart valve diseases, and congenital heart defects, Dr. Chen has made significant contributions to cardiovascular surgery. With a strong background in clinical research, Dr. Chen has published in top journals, including Nature Communications. Their work focuses on improving surgical outcomes through innovative techniques like valve-sparing procedures and minimally invasive interventions. Dedicated to advancing cardiac care, Dr. Chen continues to explore novel treatments and biomarkers for cardiovascular diseases, shaping the future of heart surgery in China and beyond.

AUTHOR PROFILE

Orcid Profile

🎓 EARLY ACADEMIC PURSUITS:

Dr. Ling Chen’s journey in medicine began at Fujian Medical University, where they pursued a Bachelor’s Degree in Clinical Medicine (2012-2017) . Their deep interest in cardiac surgery led them to earn a Master’s Degree in Surgery (2017-2020) , under the mentorship of Prof. Mingqiang Kang. Driven by a passion for advanced surgical techniques, Dr. Chen completed a Doctorate in Surgery (2020-2023) , under Prof. Liangwan Chen, focusing on groundbreaking cardiovascular research.

🏥 PROFESSIONAL ENDEAVORS:

Currently serving as a Resident Physician in the Department of Cardiac Surgery (August 2023 – Present) at Fujian Medical University Affiliated Union Hospital, Dr. Chen specializes in:
✔ Aortic Dissection
✔ Aneurysms
✔ Heart Valve Diseases
✔ Coronary Heart Disease
✔ Congenital Heart Defects

Dr. Chen is actively involved in clinical surgeries and research, aiming to improve surgical outcomes through minimally invasive techniques and innovative treatments.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON CARDIAC SURGERY:

Dr. Chen’s research bridges clinical application and scientific discovery, significantly contributing to the field of cardiac surgery and cardiovascular medicine. Their key research areas include:
✅ Pathogenesis of Aortic Dissection – Investigating the underlying mechanisms to improve early diagnosis and treatment.
✅ Factors Influencing Long-Term Prognosis of Minimally Invasive Surgery for Congenital Heart Disease – Enhancing post-surgical outcomes for pediatric and adult patients.

During their tenure at Beijing University School of Basic Medical Sciences (June 2022 – June 2023) , under the mentorship of Prof. Zheng Lemin, Dr. Chen worked on:
✔ Screening and Validation of Novel Biomarkers for Cardiovascular Diseases – Identified potential biomarkers for early cardiovascular disease detection.
✔ Gene Function in Heart Development and Disease – Discovered two new genes linked to heart developmental defects, improving genetic insights into congenital heart conditions.

🌍 IMPACT AND INFLUENCE:

Dr. Chen’s work has far-reaching implications in cardiac surgery and precision medicine:
🔹 Advancing diagnostic tools for cardiovascular diseases using genetic research.
🔹 Improving minimally invasive surgical procedures to enhance patient recovery.
🔹 Integrating biomarker research into clinical applications for early disease detection.

Their dedication to bridging research and clinical practice is helping shape the future of cardiovascular medicine.

📖 ACADEMIC CITES AND PUBLICATIONS:

Dr. Chen’s groundbreaking research has been featured in leading journals, including:
📄 “Propensity Score Matching Analysis of Valve-Sparing Versus Aortic Root Replacement in Type A Aortic Dissection Patients” (Nature Communications, 2025)

This study provides critical insights into optimizing surgical strategies for complex cardiac conditions.

🏆 LEGACY AND FUTURE CONTRIBUTIONS:

Dr. Ling Chen is committed to transforming cardiovascular healthcare through innovation. Their vision for the future includes:
✔ Developing novel surgical approaches to treat heart diseases more effectively.
✔ Expanding research on genetic and molecular mechanisms of cardiovascular disorders.
✔ Enhancing patient outcomes through personalized medicine and advanced diagnostics.

With a strong foundation in surgery, research, and clinical expertise, Dr. Chen continues to pioneer advancements in cardiac surgery, ensuring a lasting impact in the medical field.

🌍CONCLUSION:

Dr. Ling Chen’s dedication to cardiac surgery and research has greatly advanced treatments for aortic dissection, heart valve diseases, and congenital heart defects 🫀. Their expertise in minimally invasive techniques and commitment to improving patient outcomes have led to groundbreaking contributions in the field. With prestigious publications , innovative surgical techniques , and a passion for discovery, Dr. Chen continues to shape the future of cardiovascular medicine . Their work not only enhances surgical precision but also paves the way for new advancements , ensuring better healthcare for patients worldwide.

TOP NOTABLE PUBLICATION

“Propensity score matching analysis of valve-sparing versus aortic root replacement in type A aortic dissection patients”:

Authors: Ling Chen, Yichao Pan, Huaijian Zhang, Yi Chen, Chunsheng Wang, Zhihuang Qiu, Heng Lu, Liangwan Chen.

Journal: Nature Communications

Year: 2025

Yan Shi | Congenital Heart Defects | Best Researcher Award