Irene Aracil | Congenital Heart Defects | Young Researcher Award

Published on by Cardiology and Cardiovascular Medicine

Ms. Irene Aracil | Congenital Heart Defects | Young Researcher Award

Hospital Fundación Alcorcón | Spain

Ms. Irene Aracil is a medical specialist in Obstetrics and Gynecology at Hospital Universitario Fundación Alcorcón, recognized for her expertise in maternal and fetal medicine. She completed advanced training in obstetrics, gynecology, and human reproduction at leading Spanish institutions and is pursuing a doctoral degree focused on severe preeclampsia and its long-term cardiovascular effects on women’s health. Her research aims to improve maternal and perinatal outcomes through evidence-based and collaborative approaches. Ms. Aracil Moreno has authored 34 indexed publications and several book chapters, with an h index of 5 and a growing number of citations. Her main areas of study include high risk pregnancies, hypertensive disorders of pregnancy, fertility, and gynecological oncology. She has led and contributed to case control and cohort studies on preeclampsia, maternal outcomes in women with heart disease, and acute kidney injury in pregnancy, as well as meta analyses on triplet pregnancies and uterine sarcomas. Through her multidisciplinary collaborations, she bridges obstetrics and cardiovascular research, providing insights into how pregnancy complications affect long-term health. Her scientific work and clinical dedication continue to advance women’s health, making her a leading young researcher in the field of obstetrics and gynecology.

Profiles: Scopus | Orcid

Featured Publications

Aracil Moreno, I., Prieto-Arévalo, R., Ortega-Abad, V., Martín-Manzano, V., Pérez-Burrel, L., Fraile-López, A., Devesa-Cordero, C., Yllana-Pérez, F., Ortega, M. A., & De León-Luis, J. A. (2024). Maternal and perinatal outcomes in pregnant women with heart disease: A case-control study. Journal of Clinical Medicine, 13(17), 5084.

Aracil Moreno, I., Rodríguez-Benitez, P., Ruiz-Minaya, M., Bernal Claverol, M., Ortega Abad, V., Hernández Martin, C., Pintado Recarte, P., Yllana, F., Oliver-Barrecheguren, C., Alvarez-Mon, M., Ortega, M. A., & De Leon-Luis, J. A. (2024). Perinatal characteristics in patients with severe preeclampsia: A case-control nested cohort study. International Journal of Environmental Research and Public Health.

Aracil Moreno, I., Caballero Martín, S., Ceballos Medina, A., Díaz-Crespo, F. J., Navarro, [initial missing], Ortega Abad, V., León-Luis, J. A., & Mata, F. (2021). Perinatal findings and outcomes in a very rare congenital bulky retroperitoneal Ewing sarcoma: A case report. Pediatric Hematology Oncology Journal.

Rodríguez-Benitez, P., Aracil Moreno, I., Oliver Barrecheguren, C., Cuñarro López, Y., Yllana, F., Pintado Recarte, P., et al. (2021). Maternal-perinatal variables in patients with severe preeclampsia who develop acute kidney injury. Journal of Clinical Medicine, 10(23), 5629.

Ruiz-Minaya, M., Mendizabal-Vicente, E., Vasquez-Jimenez, W., Perez-Burrel, L., Aracil-Moreno, I., Agra-Pujol, C., Bernal-Claverol, M., Martínez-Bernal, B. L., Muñoz-Fernández, M., Morote-Gonzalez, M., Ortega, M. A., Lizarraga-Bonelli, S., & De Leon-Luis, J. A. (2022). Retrospective analysis of patients with gynaecological uterine sarcomas in a tertiary centre. Journal of Personalized Medicine, 12(2), 222.

Yan Shi | Congenital Heart Defects | Best Researcher Award

Published on by Cardiology and Cardiovascular Medicine

Dr. Yan Shi | Congenital Heart Defects | Best Researcher Award

Guangdong Provincial People's Hospital | China

Author Profile:

Scopus

Orcid

🌟 DR. YAN SHI: PIONEERING GENETICS RESEARCHER IN CARDIOVASCULAR DEVELOPMENT 🧬❤️

🎓 EARLY ACADEMIC PURSUITS

Yan Shi , a dedicated scientist from China, embarked on her academic journey in the field of life sciences with an undergraduate degree in Biological Engineering from Shenyang University (2008-2012). She continued to follow her passion for genetics at Hunan Normal University, earning a Master’s Degree in Genetics (2012-2014), and later completed her Ph.D. in Genetics in 2019. Throughout her studies, she developed a strong foundation in molecular biology, focusing on the genetic mechanisms underlying human diseases.

🏥 PROFESSIONAL ENDEAVORS

After obtaining her Ph.D., Dr. Yan Shi advanced her career through postdoctoral research at the Department of Pediatric Cardiac Surgery, Guangdong Provincial People's Hospital (2019-2024). In July 2024, she took on a significant role as a Researcher at the South China Key Laboratory of Structural Heart Disease, where she continues to contribute to groundbreaking cardiovascular research.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS ON CONGENITAL HEART DEFECTS

Dr. Yan Shi's primary research focuses on the molecular mechanisms of congenital and familial heart diseases, especially:

  • Tetralogy of Fallot (TOF)

  • Familial Dilated Cardiomyopathy (DCM)

  • Wnt signaling pathways in cardiac development

  • Single coronary artery animal models

She has successfully led and participated in several national-level projects, including:

  • SORBS2's role in familial dilated cardiomyopathy via the AKT pathway (2024-2027).

  • NOTCH1 point mutations leading to Tetralogy of Fallot (2022-2024).

  • Establishing an animal model for single coronary artery using mice (2020-2022).

🏅 IMPACT AND INFLUENCE

Dr. Yan Shi’s work has been widely recognized in the academic community. She has published several influential papers in reputable journals as the first, co-first, or corresponding author, covering:

  • Wnt signaling and cardiomyocyte differentiation

  • NOTCH1 mutations in congenital heart disease

  • Genetic polymorphisms in BVES associated with Tetralogy of Fallot

Additionally, she was a contributor to a team that won the First-Class Guangdong Natural Science Award (2020) for their research on genes regulating cardiovascular development.

📚 ACADEMIC CITES

Her published research has been cited in various genetic, developmental biology, and cardiovascular journals. Some of her notable publications include:

  • "Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease" – Corresponding Author

  • "Novel biphasic mechanism of the canonical Wnt signaling component PYGO2 promotes cardiomyocyte differentiation" – First Author

  • "Structure and function of Pygo in organ development" – First Author

🚀 LEGACY AND FUTURE CONTRIBUTIONS

As an emerging leader in the field of genetic cardiology, Dr. Yan Shi’s legacy is shaped by her contributions to understanding the genetic underpinnings of heart disease, which hold promise for improving clinical diagnostics and therapies for congenital heart conditions. Her future work is expected to explore further genetic pathways and their therapeutic targeting, potentially leading to personalized treatments for heart diseases.

📑 NOTABLE PUBLICATIONS

"Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUCMSCs"

Authors: Y Shi, B Qin, X Fan, Y Li, Y Wang, W Yuan, Z Jiang, P Zhu, J Chen, Y Chen, F Li, Y Wan
Journal: Cell and Tissue Research
Year: 2023

"Structure and function of Pygo in organ development dependent and independent Wnt signalling"

Authors: Y Shi, X Wu, S Zhu, H Huang, J Zhuang, H Yuan, W Yuan, P Zhu
Journal: Biochemical Society Transactions
Year: 2020