Dr. Lingyan Chen | Cardiovascular Diseases | Best Researcher Award
Dr. Lingyan Chen, Wenzhou Medical university, China
Dr. Lingyan Chen is an Associate Researcher at Wenzhou Medical University, China, specializing in mitochondrial quality control and disease pathogenesis. She holds a Ph.D. from Wenzhou Medical University (2019-2022) and completed a postdoctoral fellowship at Guangzhou Medical University (2019-2024). Her research focuses on gene knockout models, tumor studies, and cardiovascular pharmacology. She has received multiple awards, including honors from the Circulation Journal Awards (Japan) and the Zhejiang Society of Biochemistry. With extensive experience in molecular biology techniques, Dr. Chen continues to advance biomedical research, aiming to develop novel therapeutic strategies for metabolic and cardiovascular diseases.
AUTHOR PROFILE
๐EARLY ACADEMIC PURSUITS:
Dr. Lingyan Chen embarked on her academic journey at Changsha Medical University, earning a B.Sc. degree (2006-2009). She then pursued a M.Sc. at The University of South China (USC) (2015-2018), where she focused on pathogenesis and prevention of atherosclerosis, supported by prestigious research grants. She completed her Ph.D. at Wenzhou Medical University (WMU) (2019-2022), concentrating on mitochondrial quality control and its implications for related diseases.
๐ฅPROFESSIONAL ENDEAVORS:
๐น Guangzhou Medical University (Postdoctoral Researcher) (2019-2024) โ Advanced research in mitochondrial pathogenesis and disease modeling.
๐น Guangzhou Medical School (Assistant Professor) (2018) โ Engaged in pharmacology research on cardiovascular diseases.
๐น Guangzhou Medical University (Research Assistant) (2018) โ Coordinated multi-institutional research projects and managed key laboratory operations.
๐น The Second Peopleโs Hospital of Changde (Pediatric Nurse) (2009-2015) โ Provided clinical care for newborns and critically ill children, mentoring trainee nurses.
๐ฌCONTRIBUTIONS AND RESEARCH FOCUS ON CARDIOVASCULAR DISEASES:
Dr. Chenโs research spans multiple domains in biomedical sciences, including:
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Mitochondrial Quality Control & Disease Mechanisms โ Investigated gene knockout/knockin mice models, heterogeneous tumors, and disease modeling for liver cancer and diabetes.
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Cardiovascular Pharmacology โ Conducted Western Blotting, qPCR, immunofluorescence, and genetic experiments on macrophage behavior.
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Atherosclerosis & Hypertriglyceridemia โ Studied clinical patient data, serum sample analysis, and statistical evaluations to uncover disease mechanisms.
๐IMPACT AND INFLUENCE:
Dr. Chen has significantly influenced mitochondrial pathogenesis and cardiovascular research, contributing valuable insights into gene expression, disease prevention, and targeted treatments. Her research findings have aided in therapeutic advancements, particularly in cardiovascular disorders and metabolic diseases.
๐ACADEMIC CITES & LEGACY:
Dr. Chenโs research has been published in top-tier scientific journals, earning citations in the fields of biochemistry, molecular biology, and cardiovascular medicine. Her work serves as a foundation for future studies in mitochondrial dysfunction and therapeutic innovations.
๐FUTURE CONTRIBUTIONS & VISION:
As an Associate Researcher at Wenzhou Medical University (2025-Present), Dr. Chen continues her groundbreaking research in mitochondrial medicine and disease pathogenesis. She aims to:
๐น Develop novel therapeutic strategies for cardiovascular and metabolic disorders.
๐น Expand research on genetic and molecular mechanisms underlying disease progression.
๐น Mentor the next generation of biomedical researchers and medical professionals.
๐AWARDS AND HONORS:
๐น 2020 โย Second Prize in the 16th Graduate Academic Competition, Wenzhou Medical University
๐น 2020 โย Second Prize in the “Xinzhi” Youth Forum, Zhejiang Society of Biochemistry and Molecular Biology
๐น 2018 โย Second Prize for Excellent Experimental Research Paper, Circulation Journal Awards (Japan)
๐น 2018 โย Outstanding Communist of the University of South China
๐น 2017 โย 3rd Prize, Young Investigator Oral Presentation, 14th National Conference on Atherosclerotic Diseases & China-Canada Symposium
๐น 2017 โย Excellence Award, Young Investigator Oral Presentation, Cross-Strait Cardiovascular Science Symposium
๐น 2017 โย 1st Scholarship, University of South China
๐น 2016 โย 2nd Scholarship, University of South China
๐น 2015 โย 2nd Scholarship, University of South China
๐CONCLUSION:
Dr. Lingyan Chenโs dedication to biomedical research, particularly in mitochondrial quality control and cardiovascular pharmacology, has significantly contributed to understanding disease mechanisms and potential treatments. Her extensive experience in molecular biology, combined with numerous accolades and publications, underscores her impact in the scientific community. As she continues her research at Wenzhou Medical University, Dr. Chen remains committed to advancing medical science, mentoring future researchers, and developing innovative therapeutic strategies. Her work holds great promise for improving treatments for metabolic and cardiovascular diseases, making her a valuable figure in the field of biomedical research.
TOP NOTABLE PUBLICATIONS
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis
Authors: Chen, Lingyan; Chen, Dejian; Pan, Yiming; Zhang, Dawei; Xia, Xiaodan
Journal: Cell Death and Disease
Year: 2024
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells
Authors: Chen, Lingyan; Chen, Dejian; Li, Jiwei; Lu, Xiaoang; Lu, Bin
Journal: Cell Death and Disease
Year: 2022
MicroRNA-377 inhibits atherosclerosis by regulating triglyceride metabolism through the DNA methyltransferase 1 in apolipoprotein E-knockout mice
Authors: Chen, Lingyan (First Author); Xia, Xiaodan; Zhao, Zhiwei; Gong, Dan; Ma, Xuefeng; Yu, Xuhui; Zhang, Qi; Wang, Shengqi; Dai, Xinyu; Zheng, Xianliang; Zhang, Dawei; Yin, Wende; Tang, ChaoKun
Journal: Circulation Journal
Year: 2018
Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells
Authors: Xia, Xiaodan; Yu, Xuhui; Chen, Lingyan (Co-first Author); Xie, Shuo; Feng, Yan; Yang, Rui; Zhao, Zhiwei; Li, Hui; Wang, Gang; Tang, ChaoKun
Journal: Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids
Year: 2021
Heart shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway
Authors: Zhao, Zhiwei; Zhang, Min; Chen, Lingyan (Co-first Author); Gong, Dan; Xia, Xiaodan; Yu, Xuhui; Wang, Shengqi; Ou, Xue; Dai, Xinyu; Zheng, Xianliang; Zhang, Dawei; Tang, ChaoKun
Journal: Biochimica et Biophysica Acta
Year: 2018
Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages
Authors: Li, ChaoHui; Gong, Dan; Chen, Lingyan (Co-first Author); Zhang, Min; Xia, Xiaodan; Cheng, Hongping; Huang, Chen; Zhao, Zhiwei; Zheng, Xianliang; Tang, XueEr; Tang, ChaoKun
Journal: European Journal of Pharmacology
Year: 2017
IL-8 negatively regulates ABCA1 expression and cholesterol efflux via upregulating miR-183 in THP-1 macrophage-derived foam cells
Authors: Tang, XueEr; Li, Hui; Chen, Lingyan (Co-first Author); Xia, Xiaodan; Zhao, Zhiwei; Zheng, Xianliang; Zhao, GuoJun; Tang, ChaoKun
Journal: Cytokine
Year: 2019