Zhi-Hui Zhu | Cardiovascular Researches | Innovative Research Award

Published on by Cardiology and Cardiovascular Medicine

Innovative Research Award

Zhi-Hui Zhu
Zhejiang University, China
Zhi-Hui Zhu
Affiliation Zhejiang University
Country China
Scopus ID 57199280440
Documents 4
Citations 73
h-index 3
Subject Area Cardiovascular Researches
Event International Research Awards on Cardiology & Cardiovascular Medicine

The Innovative Research Award recognizes scholarly achievements that have contributed to the advancement of biomedical and life science research. Zhi-Hui Zhu of Zhejiang University has developed a research profile characterized by investigations into liver development, regenerative biology, molecular genetics, and experimental disease modeling. Through studies employing zebrafish and mammalian systems, Zhu has contributed to understanding developmental regulation, tissue regeneration, and cellular lineage mechanisms relevant to human health and disease.[1] The body of work demonstrates interdisciplinary integration of genetics, developmental biology, and translational biomedical research, providing a foundation for future applications in regenerative medicine and cardiovascular-related biological investigations.[2]

Abstract

This article summarizes the scientific contributions of Zhi-Hui Zhu in developmental biology and regenerative research. The documented publications explore liver organogenesis, gene regulation, tissue regeneration, and transgenic model development. Collectively, these studies have contributed to understanding molecular pathways that govern organ formation and repair, providing insights applicable to broader biomedical and cardiovascular research contexts.[3]

Keywords

Developmental biology; Regenerative medicine; Zebrafish genetics; Liver development; Molecular signaling; Tissue regeneration; Functional genomics; Biomedical research.

Introduction

Modern biomedical research increasingly relies on model organisms to uncover mechanisms underlying organ development and disease progression. Zhu’s investigations have focused on genetic and cellular pathways involved in liver biology, utilizing zebrafish and mammalian systems to evaluate developmental processes and regenerative responses. These studies provide mechanistic evidence supporting the role of specific genes and signaling networks in maintaining tissue integrity and recovery following injury.[1][3]

Research Profile

Affiliated with Zhejiang University, Zhi-Hui Zhu has authored and co-authored peer-reviewed publications indexed in major scientific databases. The available metrics indicate four indexed documents, seventy-three citations, and an h-index of three. Research themes encompass developmental genetics, liver biology, transgenic technologies, and regenerative mechanisms, reflecting a consistent commitment to experimentally driven biological inquiry.[1]

Research Contributions

Among Zhu’s notable contributions is the characterization of liver-enriched gene family members essential for normal liver development in zebrafish, expanding knowledge of organogenesis and developmental regulation.[2] Additional investigations examined expression patterns of homologous genes in mammalian systems, providing comparative biological insights.[3] Research on Def haploinsufficiency demonstrated activation of p53-dependent TGFβ signaling during regenerative responses, revealing mechanisms associated with scar formation following partial hepatectomy.[4] Zhu also contributed to transgenic zebrafish methodologies supporting functional genomic analysis of candidate genes involved in tumor pathogenesis.[5]

Publications

  • Chang CQ et al. (2011). Liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish.
  • Zhu ZH et al. (2012). Analysis of expression pattern of zebrafish leg1 homologous gene mu-leg1 in mouse.
  • Zhu ZH et al. (2014). Haploinsufficiency of Def activates p53-dependent TGFβ signalling and causes scar formation after partial hepatectomy.
  • Ung CY et al. (2015). Mosaic zebrafish transgenesis for functional genomic analysis of cooperative genes in tumor pathogenesis.
  • Gao C et al. (2018). Hepatocytes in a normal adult liver are derived solely from embryonic hepatocytes.

Research Impact

The research portfolio has contributed valuable evidence regarding developmental pathways, tissue regeneration, and cellular lineage tracing. These findings support broader scientific efforts aimed at understanding disease mechanisms and regenerative therapies. The citation record further indicates continued scholarly engagement with the published findings, particularly in developmental and translational biology disciplines.[1][6]

Award Suitability

Zhu’s record demonstrates sustained contributions to biological research through original investigations, methodological development, and collaborative scientific output. The integration of developmental genetics and regenerative biology aligns with the objectives of the International Research Awards on Cardiology & Cardiovascular Medicine, particularly where fundamental biological discoveries inform future therapeutic and translational applications.[5]

Conclusion

Zhi-Hui Zhu’s scholarly contributions reflect a focused research trajectory in developmental and regenerative biology. Through investigations involving gene regulation, organ development, and cellular regeneration, the researcher has advanced scientific understanding of biological processes relevant to health and disease. The documented body of work provides a credible basis for recognition through an academic research award program.[1]

References

  1. Elsevier. (n.d.). Scopus author details: Zhi-Hui Zhu, Author ID 57199280440. Scopus.
    https://www.scopus.com/authid/detail.uri?authorId=57199280440
  2. Chang CQ, Hu MJ, Zhu ZH, et al. (2011). Liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish. PLoS ONE.
    https://doi.org/10.1371/journal.pone.0022910
  3. Zhu ZH, Hu MJ, Chang CQ, Peng JR. (2012). Analysis of expression pattern of zebrafish leg1 homologous gene mu-leg1 in mouse. Hereditas.
  4. Zhu ZH, Chen J, Xiong JW, Peng JR. (2014). Haploinsufficiency of Def Activates p53-Dependent TGFβ Signalling and Causes Scar Formation after Partial Hepatectomy. PLoS ONE.
    https://doi.org/10.1371/journal.pone.0096576
  5. Ung CY, Guo F, Zhang X, Zhu Z, Zhu S. (2015). Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis. Journal of Visualized Experiments.
    https://doi.org/10.3791/52567
  6. Gao C, Zhu Z, Gao Y, et al. (2018). Hepatocytes in a Normal Adult Liver Are Derived Solely from the Embryonic Hepatocytes. Journal of Genetics and Genomics.
    https://doi.org/10.1016/j.jgg.2017.12.003

Bart Meuris | Cardiac Devices and Implants | Innovative Research Award

Published on by Cardiology and Cardiovascular Medicine

Innovative Research Award

Bart Meuris
University Hospitals Leuven, Belgium

Bart Meuris
Affiliation University Hospitals Leuven
Country Belgium
Scopus ID 6602378855
Documents 208
Citations 7,574
h-index 37
Subject Area Cardiac Devices and Implants
Event International Research Awards on Cardiology & Cardiovascular Medicine
ORCID 0000-0001-9176-293X

Bart Meuris is a Belgian cardiovascular researcher, cardiac surgeon, and academic leader associated with University Hospitals Leuven and the Department of Cardiovascular Sciences. His scholarly work focuses on cardiac surgery, heart valve technologies, transcatheter interventions, cardiovascular biomaterials, and mechanical circulatory support systems. Through an extensive publication portfolio and sustained contributions to cardiovascular innovation, Meuris has played a significant role in advancing clinical and translational research within the field of cardiac devices and implants.[1]

Abstract

Bart Meuris has established a distinguished academic record in cardiovascular medicine through research addressing heart valve replacement, transcatheter therapies, surgical innovation, thrombosis prevention, and device performance evaluation. His work integrates engineering principles with clinical practice to improve patient outcomes in structural heart disease. With more than two hundred indexed publications and thousands of citations, his research demonstrates substantial influence within contemporary cardiovascular science.[1]

Keywords

Cardiac Surgery, Heart Valve Replacement, Transcatheter Aortic Valve Implantation, Cardiovascular Devices, Valve Durability, Mechanical Valve Thrombosis, Cardiovascular Innovation, Structural Heart Disease.

Introduction

The development of safer and more durable cardiovascular devices remains a major priority in modern medicine. Bart Meuris has contributed to this objective through investigations of surgical and transcatheter valve technologies, device-related complications, and long-term cardiovascular outcomes. His work reflects a multidisciplinary approach that combines clinical evidence, biomedical engineering, and translational research to address complex cardiovascular challenges.[2]

Research Profile

As Chair within the Department of Cardiovascular Sciences at Universitair Ziekenhuis Leuven, Meuris has maintained active involvement in research concerning prosthetic heart valves, cardiovascular surgery, hemodynamics, and implant performance assessment. His scholarly output spans clinical studies, registry analyses, experimental investigations, and collaborative international projects. The breadth of his publication record reflects sustained engagement with emerging cardiovascular technologies and evidence-based treatment strategies.[3]

Research Contributions

  • Investigated Factor XI inhibition strategies for preventing mechanical valve thrombosis in experimental models.[4]
  • Evaluated sex-related outcomes following sutureless aortic valve replacement using registry-based evidence.[5]
  • Examined the current status and future development of rapid deployment valve technologies.[6]
  • Studied durability and hemodynamic performance of transcatheter valves used in aortic stenosis treatment.[7]

Publications

Recent publications authored or co-authored by Meuris include studies on Factor XI inhibition for mechanical valve thrombosis prevention, sex-related outcomes following Perceval Plus valve replacement, rapid deployment valve technologies, transcatheter valve durability, and cerebrovascular complications following transcatheter aortic valve implantation. These works collectively address clinical efficacy, procedural safety, and long-term device performance.[4][7]

Research Impact

The measurable influence of Meuris’s research is reflected by an h-index of 37, more than 7,500 citations, and a substantial body of peer-reviewed publications. His investigations have contributed to understanding cardiovascular device performance, surgical outcomes, and thrombosis prevention strategies, supporting evidence-based advancements in cardiovascular medicine and cardiac surgery.[1]

Award Suitability

Bart Meuris demonstrates qualifications aligned with the objectives of the International Research Awards on Cardiology & Cardiovascular Medicine. His sustained publication record, leadership within cardiovascular sciences, and contributions to cardiac device innovation illustrate a commitment to advancing clinical research and improving cardiovascular healthcare delivery. The scope and impact of his work support consideration for recognition under the Innovative Research Award category.

Conclusion

Through extensive research in heart valve technologies, cardiovascular implants, and surgical innovation, Bart Meuris has contributed meaningful knowledge to the field of cardiovascular medicine. His combination of academic leadership, scientific productivity, and translational research impact positions him as a notable contributor to contemporary cardiac science and device development.

References

  1. Elsevier. (n.d.). Scopus author details: Bart Meuris, Author ID 6602378855. Scopus.
    https://www.scopus.com/authid/detail.uri?authorId=6602378855
  2. ORCID. (n.d.). Bart Meuris Research Profile.
    https://orcid.org/0000-0001-9176-293X
  3. Universitair Ziekenhuis Leuven. (2024). Department of Cardiovascular Sciences Employment Record.
  4. Meuris, B. et al. (2026). Factor XI inhibition with gruticibart prevents mechanical valve thrombosis in a porcine pulmonary model.
    DOI: https://doi.org/10.1016/j.bvth.2026.100168
  5. Meuris, B. et al. (2026). Sex-related outcome after sutureless aortic valve replacement with Perceval Plus.
    DOI: https://doi.org/10.1093/icvts/ivag170
  6. Meuris, B. et al. (2026). Rapid deployment valves: current position on the market and future directions.
    DOI: https://doi.org/10.1080/17434440.2026.2638363
  7. Meuris, B. et al. (2026). Hemodynamic performance and durability of transcatheter valves for native aortic valve stenosis.
    DOI: https://doi.org/10.1080/00015385.2025.2576449

Zhihui Zhang | Cardiovascular Research | Best Researcher Award

Published on by Cardiology and Cardiovascular Medicine

Prof. Zhihui Zhang | Cardiovascular Research | Best Researcher Award

Prof. Zhihui Zhang, Army Medical University, China

Prof. Zhihui Zhang is a distinguished researcher at Army Medical University, China, specializing in cardiovascular diseases and stem cell therapy. His work focuses on endothelial seed cells, myocardial infarction, and immunosuppressive capabilities of mesenchymal stem cell-derived extracellular vesicles. He has published extensively in leading journals such as Genes and Diseases, Science Bulletin, and Stem Cell Research and Therapy. Prof. Zhang’s research contributes to advancing early diagnosis and targeted interventions for coronary microvascular dysfunction. His expertise in molecular biology and regenerative medicine has made significant impacts in cardiovascular research and clinical applications.

AUTHOR PROFILE

Scopus Profile

Orcid Profile

🎓EARLY ACADEMIC PURSUITS:

Prof. Zhihui Zhang embarked on his academic journey with a deep passion for cardiovascular medicine. His early education laid a strong foundation in medical sciences, leading him to specialize in cardiology. His dedication and excellence in research and clinical practice positioned him for advanced studies and significant contributions to the field.

🏥PROFESSIONAL ENDEAVORS:

Dr. Zhang is the Director of the Department of Cardiology at the First Affiliated Hospital (Southwest Hospital) of the Army Medical University in Chongqing. His leadership extends beyond the hospital as he holds multiple prestigious roles:

  • Member of the Great Vessel Group under the Cardiology Branch of the Chinese Medical Association
  • Member of the Cardiologists’ Association of the Chinese Medical Doctor Association
  • Deputy Director of the Committee for Structural Heart Disease under the China Human Health Promotion Association
  • Deputy Director of the Cardiology Branch of the Chongqing Medical Association, leading the Interventional Cardiology and Imaging Group

🔬CONTRIBUTIONS AND RESEARCH FOCUS ON CARDIOVASCULAR RESEARCH:

Dr. Zhang is renowned for his expertise in interventional treatment of coronary heart disease and structural heart disease. His research focuses on:

  • Precise diagnosis and treatment of coronary heart disease
  • Interventional therapy for valvular heart diseases
  • Establishing a cohort for precise classification of myocardial ischemia
  • Creating a biobank and an artificial intelligence center for coronary angiography physiological assessment

Additionally, he has developed the professional Circa Met DB database, specializing in metabolic circadian rhythms.

🌍IMPACT AND INFLUENCE:

Dr. Zhang’s contributions have earned him numerous accolades, including:
🏆 Two first prizes for scientific progress in Chongqing
🏆 One first prize for scientific progress in Hubei Province
🏆 One second prize for military medical achievements

He has successfully led over 20 research projects, ranging from national natural science funds to key military and Chongqing talent programs. His pioneering work in cardiology has influenced national and military healthcare policies.

📖ACADEMIC CITATIONS:

Dr. Zhang has an outstanding publication record, with more than 30 SCI papers as the first or corresponding author (including co-first/co-corresponding). His research has been featured in top-tier journals such as:
📌 The Lancet
📌 Nature Metabolism
📌 Nature Communications
📌 Trends in Cell Biology

Additionally, he has contributed to drafting and setting 12 expert consensus documents, served as a deputy editor for two monographs, and contributed to nine other books. His work extends to two national invention patents, further solidifying his impact in the field.

🚀LEGACY AND FUTURE CONTRIBUTIONS:

As a recipient of the Outstanding Youth Talent Fund in National Defense Bioscience, Dr. Zhang is recognized as a key innovator in cardiology. He has been honored as an Innovation Leading Talent by the Chongqing Talents Program and as a Science and Technology Talent by the Army.

His legacy will continue to shape the future of cardiovascular medicine through:
✅ Advanced research in interventional cardiology
✅ Expansion of AI-driven medical diagnostics
✅ Development of groundbreaking therapeutic techniques
✅ Mentorship and training of future cardiologists

🌟CONCLUSION:

Prof. Zhihui Zhang is a visionary leader in cardiology, blending clinical excellence, groundbreaking research, and technological innovation. His contributions have not only transformed patient care but also advanced global medical knowledge. His work will undoubtedly influence generations of medical professionals and redefine the future of cardiovascular treatment.

TOP NOTABLE PUBLICATIONS

Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction

Authors: Dingyuan Tian, Jie Li, Qingyuan Yang, Zhihui Zhang, Fang Deng

Journal: Genes and Diseases

Year: 2025

Circadian nutrition: is meal timing an elixir for fatigue?

Authors: Zhihui Zhang, Lu Yan, Jonas T. Treebak, Min-Dian Li

Journal: Science Bulletin

Year: 2025

Foxo1 drives the TGFβ1-dependent dichotomy of Th17 cell fates

Authors: Mengjuan Zhang, Yude Guan, Meijuan Han, Xiaomin Zhang, Song Zhang

Journal: Journal of Leukocyte Biology

Year: 2025

The short-term outcomes and risk factors of post-myocardial infarction ventricular septal rupture: a multi-center retrospective study

Authors: Wenjian Luo, Li Wen, Jinning Zhang, Zhexue Qin, Shiyong Yu

Journal: Journal of Cardiothoracic Surgery

Year: 2024

Sources and applications of endothelial seed cells: a review

Authors: Dan Deng, Yu Zhang, Bo Tang, Zhihui Zhang

Journal: Stem Cell Research and Therapy

Year: 2024

Enhanced immunosuppressive capability of mesenchymal stem cell-derived small extracellular vesicles with high expression of CD73 in experimental autoimmune uveitis

Authors: Yanan Duan, Xiteng Chen, Hui Shao, Jiawei Wang, Xiaomin Zhang

Journal: Stem Cell Research and Therapy

Year: 2024

Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression

Authors: Junjie Tang, Yaoming Liu, Yinghao Wang, Ping Zhang, Rong Lu

Journal: Biomarker Research

Year: 2024

Associations between non-insulin-based insulin resistance indices and heart failure prevalence in overweight/obesity adults without diabetes mellitus: evidence from the NHANES 2001–2018

Authors: Diyu Cui, Chao Zhang, Yi Chen, Yu Zhang, Ping Zhu

Journal: Lipids in Health and Disease

Year: 2024

Single-cell transcriptomics enable the characterization of local extension in retinoblastoma

Authors: Yaoming Liu, Wei Hu, Yanjie Xie, Shengli Li, Rong Lu

Journal: Communications Biology

Year: 2024

Clinical characteristics of patients with moderate or severe valvular heart disease

Authors: Hao Gao, Yuzhu Lei, Haiyun Huang, Yanxiu Chen, Zhihui Zhang

Journal: Chinese Journal of Cardiology

Year: 2024