Dr. Yu Tian | Cardiac immunology | Best Researcher Award

Dr. Yu Tian, Jiangsu University, China

Dr. Yu Tian is a prominent researcher at Jiangsu University, China, specializing in immunology and molecular biology. With a focus on immune cell migration, viral myocarditis, and neuroinflammation, Dr. Tian has contributed significantly to understanding immune responses in cardiovascular and neurological diseases. He has published numerous articles in prestigious journals such as Journal of Leukocyte Biology and International Immunopharmacology, and his research explores therapeutic targets like HMGB1 and IL-22. Dr. Tian’s work plays a critical role in advancing treatment strategies for diseases involving immune system dysfunction and inflammation.

Profile:

Scopus Profile

Education:

Dr. Yu Tian completed his Bachelor’s Degree in Medicine at Qinghai University from September 2011 to June 2016. He then pursued his Master’s and Ph.D. at Jiangsu University, School of Medicine, from September 2016 to September 2022, where he specialized in immunology and molecular biology. His academic journey has laid a strong foundation for his research in immune cell function and disease mechanisms, contributing to his current role as a researcher at Jiangsu University.

Professional Experience:

Dr. Yu Tian is currently a researcher at Jiangsu University, School of Life Sciences, specifically within the International Genomics Research Center, a position he has held since December 2022. In this role, he leads a horizontal research project investigating the effects of HMGB1 on immune cells, which commenced in 2023. Additionally, Dr. Tian is actively involved in a National Natural Science Foundation of China (NSFC)-funded project that examines the role of IGF-1 in heart damage following myocardial infarction, scheduled for 2025 to 2027. His work contributes significantly to advancing the understanding of immune mechanisms in cardiovascular health.

Research Interest:

Dr. Yu Tian’s research interests lie in immunology, specifically investigating the role of HMGB1 in immune cell responses. He focuses on cardiovascular diseases, exploring the mechanisms that contribute to heart damage and myocardial infarction. Additionally, Dr. Tian studies adipose tissue accumulation and its impact on worsening heart conditions, aiming to uncover potential therapeutic targets for improving cardiovascular health. His work seeks to enhance the understanding of immune and metabolic interactions in the context of heart disease.

Conclusion:

Dr. Yu Tian is an accomplished researcher at Jiangsu University, specializing in immunology and cardiovascular diseases. With a solid educational background and a focus on the role of HMGB1 in immune responses, he is dedicated to unraveling the complex mechanisms underlying heart damage and myocardial infarction. His ongoing research projects aim to deepen the understanding of immune cell interactions and metabolic factors that exacerbate cardiovascular conditions. Through his contributions, Dr. Tian is poised to make a significant impact on the field, advancing potential therapeutic strategies for improving heart health and addressing related diseases.

Top Notable Publications:

Yin, P., Su, Z., Shu, X., Dong, Z., Tian, Y. (2024). Role of TREM2 in immune and neurological diseases: Structure, function, and implications. International Immunopharmacology, 143, 113286. 0 citations

Tian, Y., Gong, X., Qin, D., Liu, F., Su, Z. (2023). S1PR1-dependent migration of ILC3s from intestinal tissue to the heart in a mouse model of viral myocarditis. Journal of Leukocyte Biology, 114(2), 154–163. 7 citations

Tian, Y., Chen, R., Su, Z. (2023). HMGB1 is a Potential and Challenging Therapeutic Target for Parkinson’s Disease. Cellular and Molecular Neurobiology, 43(1), 47–58. 6 citations

Chen, R., Liu, F., Xia, L., Xu, H., Su, Z. (2022). B10 cells decrease fibrosis progression following cardiac injury partially by IL-10 production and regulating hyaluronan secretion. Journal of Leukocyte Biology, 111(2), 415–425. 1 citation

Cao, Y., Tian, Y., Liu, Y., Su, Z. (2022). Reg3β: A Potential Therapeutic Target for Tissue Injury and Inflammation-Associated Disorders. International Reviews of Immunology, 41(2), 160–170. 2 citations

Che, Y., Tian, Y., Chen, R., Liu, F., Su, Z. (2021). IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C. Biochimica et Biophysica Acta – Molecular Basis of Disease, 1867(9), 166171. 26 citations

Chen, W., Yao, S., Wan, J., Yao, Y., Zhang, X. (2021). BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment. Journal of Controlled Release, 333, 129–138. 45 citations

Li, J., Xia, L., Liu, F., Chen, R., Su, Z. (2021). lncRNA187415.1 silence in BCAMs ameliorated breast cancer progression by blocking C/EBPβ-lncRNA187415.1-CISH axis and reversing pro-tumor characteristic of BCAMs. Clinical and Translational Medicine, 11(5), e407. 1 citation

Huang, L., Wan, J., Wu, Y., Su, Z., Xu, H. (2021). Challenges in adeno-associated virus-based treatment of central nervous system diseases through systemic injection. Life Sciences, 270, 119142. 26 citations

Wan, J., Wu, Y., Huang, L., Wang, S., Xu, H. (2021). ILC2-derived IL-9 inhibits colorectal cancer progression by activating CD8+ T cells. Cancer Letters, 502, 34–43. 31 citations

Dr.Stephane Manzo-Silberman | Cardiology | Best Researcher Award

Dr. Stephane Manzo-Silberman, APHP Sorbonne University, France

Dr. Stephane Manzo-Silberman is a renowned cardiologist at Assistance Publique-Hôpitaux de Paris (APHP) and a faculty member at Sorbonne University, France. She specializes in cardiovascular diseases, with a focus on coronary artery disease and interventions. Dr. Manzo-Silberman is actively involved in clinical research, particularly in the fields of interventional cardiology and thrombosis, and she has contributed extensively to academic publications in these areas. In addition to her clinical work, she plays a key role in advancing medical education and promoting innovative cardiovascular therapies.

Profile:

Scopus Profile

Education Qualification:

Dr. Stéphane Manzo-Silberman, MD, MSc, completed her medical and clinical training in cardiology at René Descartes University, Paris, where she earned her Doctorate in Medical Sciences (2005) and specialized in cardiology. She also holds a Master’s degree in Biological Sciences (2004). Her clinical expertise was further developed during her residency in internal medicine and cardiology (2000-2005), followed by advanced training as a senior resident in interventional cardiology at Cochin Hospital (2006-2011) and in coronary angiography and angioplasty at Clinique Pasteur, Toulouse (2006), under the mentorship of Pr. J Marco and Dr. J Fajadet.

Current Position:

Dr. Stéphane Manzo-Silberman currently serves as Senior Consultant at the Cardiac Catheterization Laboratory and Coronary Care Unit of the Cardiology Institute at Pitié-Salpêtrière Hospital, APHP, Sorbonne University, Paris. In this role, she specializes in interventional cardiology, managing complex cardiac procedures and providing advanced care for patients with coronary artery disease. Her position reflects her expertise in cardiovascular interventions and her dedication to improving clinical outcomes in cardiology.

Awards:

Dr. Stéphane Manzo-Silberman has received several prestigious awards throughout her career, including the French Society of Cardiology Prize for the best doctorate dissertation (2005) and the French Society of Angeology Junior Prize for the best master’s dissertation (2005). She was also honored with the Young Investigator Prize at JESFC 2017 and received an ESC Grant in 2020 to attend the Women Transforming Leadership Programme, highlighting her continued excellence in cardiology and leadership development.

Research Experience:

Dr. Stéphane Manzo-Silberman serves as the principal investigator in numerous multicenter academic clinical research studies. Her work includes leading pivotal studies such as the DOLORES registry, the DeFSSICA survey on acute heart failure management, and the First French Metaregistry on gender differences in myocardial infarction. She has also co-authored the EAPCI Women’s Survey on radiation protection in catheterization labs and chaired an EAPCI position statement on radiation protection during pregnancy for healthcare professionals. Additionally, she oversees major national projects like the WAMIF study on acute myocardial infarction in young women and the ACFA study on atrial fibrillation care pathways. Dr. Manzo-Silberman also actively directs theses and dissertations, mentoring the next generation of cardiology professionals.

Conclusion:

Dr. Stéphane Manzo-Silberman stands as a prominent figure in the field of cardiology, reflecting a deep commitment to advancing cardiovascular health and understanding. His extensive research, focused on the intricate dynamics of heart disease, particularly among diverse populations, underscores the critical importance of tailored medical approaches. Through his leadership in various studies and initiatives, Dr. Manzo-Silberman not only contributes to the scientific community but also advocates for improved patient outcomes and health equity. As he continues to explore new frontiers in cardiology, his work promises to inspire future generations of medical professionals and researchers, paving the way for innovative solutions to the challenges faced in cardiovascular care.

Top Notable Publications:

Laghlam, D., Benghanem, S., Ortuno, S., Hamzaoui, O., & Aissaoui, N. (2024). Management of cardiogenic shock: A narrative review. Annals of Intensive Care, 14(1), 45.

Sabouret, P., Barbato, E., Montalescot, G., Biondi-Zoccai, G., & Manzo-Silberman, S. (2024). Remembering our friend Jean-Philippe Collet: A giant in cardiology, a gentleman in life. Minerva Cardiology and Angiology, 72(4), 329-331.

Manzo-Silberman, S., Martin, A.-C., Boissier, F., Puymirat, E., & Delmas, C. (2024). Sex disparities in cardiogenic shock: Insights from the FRENSHOCK registry. Journal of Critical Care, 82, 154785.

Manzo-Silberman, S., Guedeney, P., Cayla, G., Montalescot, G., & Silvain, J. (2024). Ticagrelor vs Clopidogrel in Clopidogrel-Naive Patients with Chronic Coronary Syndrome. JACC: Cardiovascular Interventions, 17(12), 1413-1421.

Manzo-Silberman, S., Montalescot, G., & Lebreton, G. (2024). Has DanGer-Shock reshuffled the cards for mechanical circulatory support trials? Archives of Cardiovascular Diseases (Article in Press).

Hebbo, E., Khan, S., Manzo-Silberman, S., & Alasnag, M. (2024). The Clinical Approach to Angina in Women. Interventional Cardiology Clinics (Article in Press).

Manzo-Silberman, S., & Montalescot, G. (2023). Benefits of an observatory for myocardial infarction in women under 50: The WAMIF study. Annales de Cardiologie et d’Angeiologie, 72(6), 101691.

Manzo-Silberman, S., Chouihed, T., Ticelli, L.F., Roubille, F., & El Khoury, C. (2023). Assessment of atrial fibrillation in European emergency departments: Insights from a prospective observational multicenter study. Minerva Cardiology and Angiology, 74(4), 444-455.

Weizman, O., Tea, V., Marijon, E., Simon, T., & Danchin, N. (2023). Very long-term outcomes after acute myocardial infarction in young men and women: Insights from the FAST-MI program. Archives of Cardiovascular Diseases, 116(6-7), 324-334.

Sabouret, P., Manzo-Silberman, S., Alasnag, M., Biondi-Zoccai, G., & Bhatt, D.L. (2023). New approaches to reduce recurrent PCI: To angioplasty and beyond! European Heart Journal Open, 3(3), oead049.

Yu Tian | Cardiac immunology | Best Researcher Award